7-Amino-3-(1,3,4-thiadiazol-2-ylthiomethyl)-3cephem-4-carboxylic acid → HCID 131714116, compound

HRID 615749Notes

Reaction equation

HRID 615749 reaction equation
[O:1]1[C:6]([C:7](=[N:11][O:12][CH3:13])[C:8]([OH:10])=O)=[CH:5][S:4][CH2:3][CH2:2]1.[NH2:14][CH:15]1[C:32](=[O:33])[N:17]2[C:18]([C:29]([OH:31])=[O:30])=[C:19]([CH2:22][S:23][C:24]3[S:25][CH:26]=[N:27][N:28]=3)[CH2:20][S:21][C@H:16]12>>[O:1]1[C:6]([C:7](=[N:11][O:12][CH3:13])[C:8]([NH:14][CH:15]2[C:32](=[O:33])[N:17]3[C:18]([C:29]([OH:31])=[O:30])=[C:19]([CH2:22][S:23][C:24]4[S:25][CH:26]=[N:27][N:28]=4)[CH2:20][S:21][C@H:16]23)=[O:10])=[CH:5][S:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 128891877-Amino-3-(1,3,4-thiadiazol-2-ylthiomethyl)-3cephem-4-carboxylic acidHCID 53841578HCID 53841578, compound

Product 1

HCID 131714116HCID 131714116, compound

Procedure

2-(2,3-Dihydro-1,4-oxathiin-6-yl)-2-methoxyiminoacetic acid (syn isomer, 1 g.) was allowed to react with 7-amino-3-(1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid (1.8 g.) in a similar manner to that of Example 1 to give the captioned compound (2.3 g.), pale yellow powder, mp. 160° to 165° C. (dec.).

Workup

  1. customto give the captioned compound (2.3 g.), pale yellow powder, mp. 160° to 165° C. (dec.)

Sources & evidence

ORD record
ord-a3e1241361d741078690b0425b7fc36e
Source dataset
uspto-grants-1985_02
Patent number
US04500709

Reaction notes

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