HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 2-(3-Methylureido)thiazolo[4,5-c]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | (1,3)Thiazolo(4,5-c)pyridin-2-amine | HCID 14252938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(3-Methylureido)thiazolo[4,5-c]pyridine | HCID 15593547 | 79% |
Reaction Steps
A mixture of 2-aminothiazolo[4,5-c]pyridine (151 mg, 1 mmole), pyridine (1.8 ml), CH3NCO (1.2 ml) and 3 ml DMF was stirred at room temperature for 2 days. To the reaction mixture was added CH3OH, and the mixture was evaporated in vacuo. The residue was treated with CH3OH and ether to give 165 mg (79%) of crystalline solid. Mp. 178°~187° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04500526 |
| Source dataset | uspto-grants-1985_02 |
| ORD ID | ord-ea58295e464941029d42aaa6da532658 |
| Source note | uspto-grants-1985_02 |