Hydrazine hydrate (1:1) → 2-tert-Butyl-5-hydrazinyl-1,3,4-thiadiazole

Participants

Reaction Steps

Hydrazine hydrate (12.5 g) was added to a solution of 2-bromo-5-t-butyl-1,3,4-thiadiazole (22.1 g) in ethanol (100 ml), and the mixture was heated under reflux for 2 hours. The solvent was evaporated to give an oily solid which was crystallised from water to give 2-hydrazino-5-t-butyl-1,3,4-thiadiazole (13.7 g, 79%) as white needles, mp 111°-112° C.

Provenance & Evidence