Water → HCID 54386171, compound

Participants

Reaction Steps

Sodium hydride (0.12 g) was added to a stirred solution of acetaldehyde 5-t-butyl-1,3,4-thiadiazolyl hydrazone (0.99 g) in dry toluene (25 ml), and the mixture was stirred at room temperature for 15 minutes. 2-Methylaminocarbonyloxyimino-2-phenylacetonitrile (1.01 g) was added and the mixture was stirred for a further 2 hours and poured into water (20 ml). The organic phase was separated and dried over magnesium sulphate. The drying agent was filtered off and the toluene evaporated to give a yellow oil, purified by chromatography to give acetaldehyde 4-methyl-2-(5-t-butyl-1,3,4-thiadiazol-2-yl)semicarbazone (0.6 g, 47%) as a pale yellow oil.

Provenance & Evidence