Hydrazine hydrate (1:1) → HCID 20406533, compound

Participants

Reaction Steps

2,5-bis(ethanesulphonyl)-1,3,4-thiadiazole (67.5 g) was added portionwise to a stirred solution of hydrazine hydrate (25.8 g) in methanol (1000 ml) at room temperature. The mixture was then stirred for 20 minutes and filtered. The solid was crystallised from methanol to give 2-hydrazino-5-ethylsulphonyl-1,3,4-thiadiazole (16.5 g, mp 166°-167° C.). The corresponding semicarbazone was prepared from this compound by reaction with acetaldehyde, then with methylisocyanate by methods analogous to those of Example 1(c) and 1(d), and the title compound was generated by the method of Example 13, mp 151°-153° C.

Provenance & Evidence