HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → N-[N-[4-(2,2,2,-trifluoroethoxy)-6-methylpyrimidin-2-yl]-N-methylaminocarbonyl]-2-chloro-N-methylbenzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 2-Methylamino-4-(2,2,2-trifluorethoxy)-6-methylpyrimidine | HCID 20189867 | — |
| Reactant | N-[(2-chlorophenyl)sulfonyl]-N-methylcarbamyl chloride | HCID 20189879 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | N-[N-[4-(2,2,2,-trifluoroethoxy)-6-methylpyrimidin-2-yl]-N-methylaminocarbonyl]-2-chloro-N-methylbenzenesulfonamide | HCID 20189885 | — |
Reaction Steps
To 18 parts of N-[(2-chlorophenyl)sulfonyl]-N-methylcarbamyl chloride in 300 parts of tetrahydrofuran containing 10 parts of triethylamine is added 22 parts of 2-methylamino-4-(2,2,2-trifluoroethoxy)-6-methylpyrimidine. After stirring at reflux for 10 hours, the precipitated salts are filtered off and the filtrate is concentrated to yield N-[N-[4-(2,2,2,-trifluoroethoxy)-6-methylpyrimidin-2-yl]-N-methylaminocarbonyl]-2-chloro-N-methylbenzenesulfonamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04501607 |
| Source dataset | uspto-grants-1985_02 |
| ORD ID | ord-ceb8b823eb154a96be776ca6bc9125e0 |
| Source note | uspto-grants-1985_02 |