Phosphonic acid, (1-aminoethyl)-, diethyl ester → HCID 12673131, compound

HRID 615850Notes

Reaction equation

HRID 615850 reaction equation
[NH2:1][CH:2]([P:4](=[O:11])([O:8][CH2:9][CH3:10])[O:5][CH2:6][CH3:7])[CH3:3].[CH:12](CC(OC(=O)CC=O)=O)=[O:13]>>[CH:12]([NH:1][CH:2]([P:4](=[O:11])([O:5][CH2:6][CH3:7])[O:8][CH2:9][CH3:10])[CH3:3])=[O:13]

Participants

3

Reactant 2

HCID 5149858Phosphonic acid, (1-aminoethyl)-, diethyl esterHCID 53941097HCID 53941097, compound

Product 1

HCID 12673131HCID 12673131, compound

Conditions

Temperature
120 °C

Procedure

A mixture of 3.6 g of diethyl α-aminoethyl-phosphonate prepared by the process of Chalmers et al, J.A.C.S., Vol 75 (1953), p. 5278 and 2 g of formylacetic acid anhydride stood overnight at room temperature and was then heated at 120° C. under a pressure of 0.5 to 1 mm Hg for 15 to 20 minutes. The residue was distilled to obtain pure diethyl 1-(N-formylamino)-ethyl-phosphonate with a boiling point of 148°~150° at 0.5 mm Hg which was used as is for the next step.

Workup

  1. customprepared by the process of Chalmers et al, J.A.C.S
  2. distillationThe residue was distilled

Sources & evidence

ORD record
ord-e18a4461d52f4ca7a47cfe5eb575f40f
Source dataset
uspto-grants-1985_02
Patent number
US04501701

Reaction notes

Loading…