Ammonia → HCID 12612386, compound

HRID 615851Notes

Reaction equation

HRID 615851 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=O)[C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[N:16]1[C:20]([CH2:21]OS(C)(=O)=O)=[N:19][N:18]=[C:17]1[CH2:27][N:28]([CH3:30])[CH3:29].[NH3:32]>CO>[Cl:15][C:13]1[CH:12]=[CH:11][C:10]2[N:16]3[C:17]([CH2:27][N:28]([CH3:30])[CH3:29])=[N:18][N:19]=[C:20]3[CH2:21][N:32]=[C:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[Cl:1])[C:9]=2[CH:14]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 20406676HCID 20406676, compound

Product 1

HCID 12612386HCID 12612386, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Derwent Abstract 48681A briefs a Japanese Patent Publication No. 59696/78, published May 29, 1978, disclosing the ring closure of 2',5-dichloro-2-[3-(dimethylaminomethyl)-5-mesyloxymethyl-4H-1,2,4-triazol-4-yl]benzophenone in a sealed tube with ammonia containing methanol to obtain 8-chloro-6-(2-chlorophenyl)-1-[(dimethylamino)methyl]-4H-s-triazolo[4,3-a][1,4]benzodiazepine. However, sealed tube procedures are not practical for commercial scale chemical process operations, and the abstract does not disclose how the (3-hydroxymethyl-triazol-4-yl)-compounds are obtained.

Sources & evidence

ORD record
ord-5a597b22f805457795b6e142806abfe3
Source dataset
uspto-grants-1985_02
Patent number
US04501698

Reaction notes

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