HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → alpha-Hydroxyalprazolam
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Estazolam | HCID 3261 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | alpha-Hydroxyalprazolam | HCID 162244 | — |
Reaction Steps
A process according to claim 2 wherein estazolam is reacted with paraformaldehyde in xylene at 120° C. to 140° C. for a time sufficient to form 1-(hydroxymethyl)-8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04501698 |
| Source dataset | uspto-grants-1985_02 |
| ORD ID | ord-51350fa13c9f4bfdae666d65b43fe170 |
| Source note | uspto-grants-1985_02 |