Dicyclohexylcarbodiimide → N-[2-(4-pyridyl)ethyl]-N-cyclohexyl-alpha-(n-butylthio)acetamide

HRID 615874Notes

Reaction equation

HRID 615874 reaction equation
[CH:1]1([NH:7][CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:16]([S:20][CH2:21][C:22](O)=[O:23])[CH2:17][CH2:18][CH3:19].C1(N=C=NC2CCCCC2)CCCCC1>ClCCl>[N:13]1[CH:14]=[CH:15][C:10]([CH2:9][CH2:8][N:7]([CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[C:22](=[O:23])[CH2:21][S:20][CH2:16][CH2:17][CH2:18][CH3:19])=[CH:11][CH:12]=1

Participants

5

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 88607(Butylthio)acetic acidHCID 255104N-(2-pyridin-4-ylethyl)cyclohexanamine

Product 1

HCID 13652435N-[2-(4-pyridyl)ethyl]-N-cyclohexyl-alpha-(n-butylthio)acetamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

N-[2-(4-pyridyl)ethyl]-N-cyclohexyl-α-(n-butylthio)acetamide was prepared by reacting 5.0 g. of N-cyclohexyl-[2-(4-pyridyl)ethyl]amine with 4.4 g. of α-(n-butylthio)acetic acid and 5.0 g. of N,N'-dicyclohexylcarbodiimide in 100 ml. of dichloromethane by the method of Example 2. Weight 2.57 g. Oil.

Sources & evidence

ORD record
ord-63608f60dfc44abab1afa8bff4befc68
Source dataset
uspto-grants-1985_02
Patent number
US04501746

Reaction notes

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