Isopropylamine → 3-Isopropylamino-1,2-propanediol
Reaction equation
[CH2:1]1[O:3][CH:2]1[CH2:4][OH:5].[CH:6]([NH2:9])([CH3:8])[CH3:7]>>[CH:6]([NH:9][CH2:1][CH:2]([OH:3])[CH2:4][OH:5])([CH3:8])[CH3:7]Participants
3
Conditions
- Temperature
- 25 °C
Procedure
A mixture of 37 g (0.5 mole) of glycidol and 35.4 g (0.6 mole) of isopropylamine was stirred at 25° C. overnight. Excess isopropylamine was evaporated in vacuo and the mixture was distilled to give 53 g of product: b.p. 80° C./0.1 mm Hg. The NMR and IR spectra were consistent with the assigned structure and the elemental analysis was consistent with the empirical formula C6H15O2N.
Workup
- customExcess isopropylamine was evaporated in vacuo
- distillationthe mixture was distilled
Sources & evidence
- ORD record
- ord-03448eb157d34819a411503f203e57be
- Source dataset
- uspto-grants-1985_02
- Patent number
- US04501912
Reaction notes
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