Diethylamine → HCID 20370812, compound

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Reaction Steps

2.04 g. of 5-chloropyrazolo[1,5-a]pyrido[3,2-e]pyrimidine of Example 1c are added to 20 ml. of diethylamine. The solution is refluxed for 5 hours. The excess diethylamine is distilled off and the residue is treated with 5 ml. water and extracted three times with 10 ml. portions of ethyl acetate. The organic layers are combined, dried over sodium sulfate, filtered and evaporated to dryness. The residual N,N-diethylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-5-amine is recrystallized from ethyl acetate/petroleum ether, yield: 2 g. (83%); m.p. 102°.

Provenance & Evidence