Ethyl orthoformate → HCID 178462997, compound

Participants

Reaction Steps

20.5 g. of 4-amino-1-ethylpyrazolo[3,4-b]pyridin-5-carboxamide are refluxed with stirring for 24 hours with 100 ml. of triethyl orthoformate. The excess ester is removed in vacuo and the residue recrystallized from dimethylformamide to obtain 7-ethyl-1,7-dihydro-4H-pyrazolo[4',3':5,6]pyrido[4,3-d]pyrimidin-4-one, yield: 19 g. (88%); m.p. 320°-322°.

Provenance & Evidence