HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 5-Methyl-2-phenyl-4-oxazolecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 5-Methyl-2-phenyl-1,3-oxazole-4-carbonyl chloride | HCID 318530 | — |
| Product | 5-Methyl-2-phenyl-4-oxazolecarboxamide | HCID 100344 | — |
Reaction Steps
9.4 Grams (0.0425 mole) of 5-methyl-2-phenyl-4-oxazolecarboxylic acid chloride is added in small portions to 200 ml. (3.33 mole) of concentrated ammonium hydroxide. The mixture is vigorously stirred and the temperature is maintained at about 0° during the addition step. After the addition, the temperature is allowed to rise to room temperature and the mixture is left standing overnight. The solid which forms is collected by filtration, washed with water, dried and recrystallized from methanol. 6.35 Grams of the title product is obtained; m.p. 154°-157° (from methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04072689 |
| Source dataset | uspto-grants-1978_02 |
| ORD ID | ord-137ac90b643b4b219407de5cef80324f |
| Source note | uspto-grants-1978_02 |