HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 4-(1-Methylpiperidin-3-yl)benzene-1,2-diol--hydrogen bromide (1/1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 3-(3,4-Dimethoxyphenyl)-1-methylpiperidine--hydrogen chloride (1/1) | HCID 20370849 | — |
| Product | 4-(1-Methylpiperidin-3-yl)benzene-1,2-diol--hydrogen bromide (1/1) | HCID 3046370 | — |
Reaction Steps
A mixture of 8 g of the product of Step D in 40 ml of 66% hydrobromic acid was refluxed for an hour and then distilled to dryness under reduced pressure. The residue was dissolved in hot ethanol and the solution was cooled and vacuum filtered to obtain 2.49 g of N-methyl-3-(3',4'-dihydroxyphenyl)-piperidine hydrobromide as crystals melting at 190° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04072685 |
| Source dataset | uspto-grants-1978_02 |
| ORD ID | ord-e632f6c0e96542b191cc20acfbc3317c |
| Source note | uspto-grants-1978_02 |