Allyl bromide → 3-(3,4-Dimethoxyphenyl)-1-(prop-2-en-1-yl)piperidine

Participants

Reaction Conditions

Reaction Steps

2.8 g of silver oxide were added to a solution of 5.6 g of 3-(3',4'-dimethoxyphenyl)-piperidine in 28 ml of acetone and then 2.3 ml of allyl bromide were added dropwise thereto with slow cooling. The mixture was stirred at 20° C for 30 minutes and was then filtered. The filtrate was evaporated to dryness and the residue was chromatographed over silica gel. Elution with a 6-3-1 cyclohexane-chloroform-triethylamine mixture yielded 5.55 g of N-allyl-3-(3',4'-dimethoxyphenyl)-piperidine.

Provenance & Evidence