HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → N-[4-(Benzylsulfanyl)-2-nitrophenyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | Thiocyanic acid, 4-(acetylamino)-3-nitrophenyl ester | HCID 8180927 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-[4-(Benzylsulfanyl)-2-nitrophenyl]acetamide | HCID 20362823 | — |
Reaction Steps
2.37 G. of 1-acetamido-2-nitro-4-thiocyanatobenzene is dissolved in 10 ml. of dimethylformamide under nitrogen and 0.38 g. of sodium borohydride added at 20°-30° C. The mixture is stirred for one hour and then 2.4 ml. of benzylbromide is added. After a further 2 hours the mixture is diluted with water and the product filtered off and washed with water and hexane. Recrystallation from methanol gives pure 1-acetamido-2-nitro-4-benzylthiobenzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04072696 |
| Source dataset | uspto-grants-1978_02 |
| ORD ID | ord-4613ec4019af4244b338f89937cf7ef2 |
| Source note | uspto-grants-1978_02 |