Chloroform → HCID 20371008, compound

HRID 616077Notes

Reaction equation

HRID 616077 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([S:11][CH2:12][CH2:13][CH3:14])=[CH:7][C:6]=1[N+:15]([O-:17])=[O:16])(=[O:3])[CH3:2].C(Cl)(Cl)Cl.C(OO)(=[O:24])C>CO>[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([S:11]([CH2:12][CH2:13][CH3:14])=[O:24])=[CH:7][C:6]=1[N+:15]([O-:17])=[O:16])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 6212ChloroformHCID 6585Peracetic AcidHCID 20362810N-[2-Nitro-4-(propylsulfanyl)phenyl]acetamide

Product 1

HCID 20371008HCID 20371008, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 3.0 g. of 1-acetamido-2-nitro-4-n-propylthiobenzene in 30 ml. chloroform is cooled to -15° C. and treated with a solution of 2.5 g. of 40% peracetic acid in 4 ml. methanol. After the addition the temperature is allowed to rise slowly to 20° C whereupon the solution is washed with sodium bisulfite solution and then with sodium bicarbonate solution. The product is isolated by evaporation of the solvent and purified by treatment with ether to afford 1-acetamido2-nitro-4-n-propylsulfinylbenzene.

Workup

  1. additiontreated with a solution of 2.5 g
  2. additionAfter the addition the temperature
  3. customto rise slowly to 20° C whereupon the solution
  4. washis washed with sodium bisulfite solution
  5. customThe product is isolated by evaporation of the solvent
  6. custompurified by treatment with ether

Sources & evidence

ORD record
ord-b4d23ea647054b0c9de2c3dda3dd7f0d
Source dataset
uspto-grants-1978_02
Patent number
US04072696

Reaction notes

Loading…