Methoxycarbonyl isothiocyanate → 4-n-Butylthio-1-(3-methoxycarbonyl-2-thioureido)-2-nitrobenzene

Participants

Reaction Steps

2.5 G. of 1-amino-4-n-butylthio-2-nitrobenzene (alternatively prepared according to Example II) is dissolved in 25 ml. acetone and treated at room temperature with 3 g. methoxy carbonyl isothiocyanate. The mixture is left overnight, stripped under vacuum and the residue triturated with methanol and recrystallized from methanol to yield pure 4-n-butylthio-1-(3-methoxycarbonyl-2-thioureido)-2-nitrobenzene.

Provenance & Evidence