HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2-Nitro-4-[(prop-2-yn-1-yl)sulfanyl]aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Propargyl bromide | HCID 7842 | — |
| Reactant | 4-Amino-3-nitrophenyl thiocyanate | HCID 104677 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-Nitro-4-[(prop-2-yn-1-yl)sulfanyl]aniline | HCID 20362814 | — |
Reaction Steps
5.85 G. of 1-amino-2-nitro-4-thiocyanatobenzene in 20 ml. dimethylformamide is treated, under nitrogen, with 1.14 g. sodium borohydride at 20°-30° C. After 1 1/2 hours 5 ml. of propargyl bromide is added. The mixture is stirred for three hours at 20°-30° C, then diluted with water. The product, a red solid, is isolated by extraction into chloroform yielding 1-amino-2-nitro-4-propargylthiobenzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04072696 |
| Source dataset | uspto-grants-1978_02 |
| ORD ID | ord-ca32f4ca4a7840a5b4011f314be3cec0 |
| Source note | uspto-grants-1978_02 |