Methyl chloroformate → 1-(3-Methoxycarbonyl-2-thioureido)-5-phenylsulfinyl-2-nitrobenzene

Participants

Reaction Steps

A suspension of 5.2 g. of 1-amino-5-phenylsulfinyl-2-nitrobenzene in 50 ml. of acetone is treated at 20°-25° C with a solution of 100 ml. of methoxycarbonyl isothiocyanate (made from 0.125 mol. (each) of potassium thiocyanate and methylchloroformate) in acetone. After several days, the solvent is stripped off under vacuum and the residue triturated with ether. Recrystallization of the crude product from methanol-chloroform yields 1-(3-methoxycarbonyl-2-thioureido)-5-phenylsulfinyl-2-nitrobenzene.

Provenance & Evidence