反应详情

In a similar manner, substituting 1-amino-4-carbamoylthio-2-nitrobenzene for the 4-carbamoylthio-1-(3-methoxycarbonyl-2-thioureido)-2-nitrobenzene in the iron reduction step, 1,2-diamino-4-carbamoylthiobenzene is prepared. 0.5 G. of this latter compound in 30 ml. acetone is treated overnight with 2 g. methoxy carbonyl isothiocyanate at room temperature. The solution is concentrated and the residue triturated with ether. Recrystallization yields 4-carbamoylthio-1,2-bis-(3-methoxycarbonyl-2-thioureido)-benzene.

1. customis prepared
2. customat room temperature
3. concentrationThe solution is concentrated
4. customthe residue triturated with ether
5. customRecrystallization