Methane → HCID 21822417, compound

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Reaction Steps

2.1 G. of 1-amino-4-n-butoxy-2-nitrobenzene, prepared according to Example XXXV, and 1 g. of 5% palladized charcoal in 100 ml. methanol are treated with hydrogen at atmospheric pressure until the theoretical uptake of hydrogen has occurred. The mixture is filtered and the filtrate evaporated to give 1,2-diamino-4-n-butoxybenzene. This is treated, in 60 ml. acetone, with 7.0 g. methoxycarbonyl isothiocyanate. The mixture is kept at room temperature overnight and then concentrated under vacuum. The residue is stirred with water, filtered and recrystallized from dichloromethane/benzene yielding 1,2-bis-(3-methoxycarbonyl-2-thioureido)-4-n-butoxybenzene.

Provenance & Evidence