Methanol → HCID 20371152, compound

HRID 616141Notes

Reaction equation

HRID 616141 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([S:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:11])[CH:7]=[CH:6][C:5]=1[NH:18][C:19]([NH:21][C:22]([O:24][CH3:25])=[O:23])=[S:20])([O-])=O.CO.S(S([O-])=O)([O-])=O.[Na+].[Na+]>O>[NH2:1][C:4]1[CH:9]=[C:8]([S:10]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[O:11])[CH:7]=[CH:6][C:5]=1[NH:18][C:19]([NH:21][C:22]([O:24][CH3:25])=[O:23])=[S:20]

Participants

5

Reactant 3

HCID 887MethanolHCID 24489Sodium DithioniteHCID 203711422-Nitro-4-phenylsulfinyl-1-(3-methoxycarbonyl-2-thioureido)benzene

Product 1

HCID 20371152HCID 20371152, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.5 G. of 2-nitro-4-phenysulfinyl-1-(3-methoxycarbonyl-2-thioureido)benzene is dissolved in a hot mixture of 450ml. of methanol and 200ml. of water. 15 G. of sodium hydrosulfite is added and, after boiling for 10 minutes, the solution is concentrated. The mixture is diluted with water, extracted thoroughly with chloroform and the product isolated by evaporation of the chloroform. Recrystallizing from methanol-chloroform yields 2-amino-1-(3-methoxycarbonyl-2-thioureido)-4-phenylsulfinylbenzene.

Workup

  1. concentrationthe solution is concentrated
  2. additionThe mixture is diluted with water
  3. extractionextracted thoroughly with chloroform
  4. customthe product isolated by evaporation of the chloroform
  5. customRecrystallizing from methanol-chloroform

Sources & evidence

ORD record
ord-3e17566eb1ea4b468937b8c9f7be6c91
Source dataset
uspto-grants-1978_02
Patent number
US04072696

Reaction notes

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