Methoxycarbonyl isothiocyanate → 1-(3-Methoxycarbonyl-2-thioureido)-2-nitro-4-(2-phenoxyethoxy)benzene

Participants

Reaction Steps

The 1-amino-2-nitro-4-(2-phenoxyethoxy)benzene so obtained is treated with methoxycarbonyl isothiocyanate (as per Example XL) to afford 1-(3-methoxycarbonyl-2-thioureido)-2-nitro-4-(2-phenoxyethoxy)benzene which is reduced with sodium hydrosulfite (as per Example XXI) or iron-ferrous sulfate (as per Example VII) to afford 1-(3-methoxycarbonyl-2-thioureido)-2-amino-4-(2-phenoxyethoxy)benzene. The latter compound is further reacted with another equivalent of methoxycarbonyl isothiocyanate to afford 1,2-bis-(3-methoxycarbonyl-2-thioureido)-4-(2-phenoxyethoxy)benzene.

Provenance & Evidence