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HRID616169

反应详情

EQUATION

反应方程式

HRID 616169 的结构方程式

REACTANTS

反应物

2
结构：CN=C(NS(=O)(=O)c1ccc(Cl)cc1)SC
HCID22756462

未命名化合物

结构：Cc1nc[nH]c1CSCCN
HCID178433288

未命名化合物

PRODUCTS

生成物

1
结构：CNC(=NCCSCc1[nH]cnc1C)NS(=O)(=O)c1ccc(Cl)cc1
HCID178485013

未命名化合物

收率 59.1%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

A solution of 4-methyl-5-((2-aminoethyl)thiomethyl)imidazole (3.33 g.) and N-(4-chlorobenzenesulphonyl)-N' ,S-dimethylisothiourea (5.40 g.) in acetonitrile was heated under reflux for 24 hours. Concentration, followed by recrystallisation from aqueous ethanol afforded N-(4-chlorobenzenesulphonyl)-N'-methyl-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine (4.6 g.), m.p. 153°-154°.

WORKUP

后处理

  1. temperatureunder reflux for 24 hours
  2. concentrationConcentration
  3. customfollowed by recrystallisation from aqueous ethanol