Hydrogen chloride-ethyl acetate → HCID 178449159, compound

HRID 616180Notes

Reaction equation

HRID 616180 reaction equation
[N:1]#[N:2].C([O:7][C:8](=[O:36])[CH2:9][N:10]([C:15](=[O:35])[C@H:16]([CH2:28][CH2:29][CH2:30][NH:31][C:32](=[NH:34])[NH2:33])[NH:17][S:18]([C:21]1[CH:27]=[CH:26][C:24]([CH3:25])=[CH:23][CH:22]=1)(=[O:20])=[O:19])[CH2:11][CH2:12][CH2:13][CH3:14])(C)(C)C.[ClH:37].C(OCC)(=O)C>C(Cl)(Cl)Cl>[N:1]#[N:2].[ClH:37].[S:18]([NH:17][C@H:16]([C:15]([N:10]([CH2:11][CH2:12][CH2:13][CH3:14])[CH2:9][C:8]([OH:36])=[O:7])=[O:35])[CH2:28][CH2:29][CH2:30][NH:31][C:32](=[NH:33])[NH2:34])([C:21]1[CH:27]=[CH:26][C:24]([CH3:25])=[CH:23][CH:22]=1)(=[O:19])=[O:20]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178449152HCID 178449152, compound

Product 1

HCID 178449159HCID 178449159, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 2.0 g of N2 -tosyl-L-arginyl-N-butylglycine tert-butyl ester in 20 ml of chloroform was added 50 ml of 15% HCl-ethyl acetate. The reaction mixture was stirred for 5 hours at room temperature. At the end of this period, the reaction mixture was evaporated to dryness. The residue was washed several times with dry ethyl ether to give 1.5 g of N2 -tosyl-L-arginyl-N-butylglycine hydrochloride as an amorphous solid.

Workup

  1. customAt the end of this period, the reaction mixture was evaporated to dryness
  2. washThe residue was washed several times with dry ethyl ether

Sources & evidence

ORD record
ord-b867bb70d3d1431eb703c63b454d3083
Source dataset
uspto-grants-1978_02
Patent number
US04072743

Reaction notes

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