反应详情

To a suspension of 1.48 g (5.0 mmol) of 4-(4-phthalimidobutyloxy)pyridine in 20 ml of methanol, 15 ml of hydrogen chloride-methanol was added and dissolve. The solvent was distilled off and the residue was crystallized from acetone-ether. The resulting crystals were collected by filtration and washed with ether to give 1.51 g of the desired compound (86.3% yield, colorless crystals), mp. 154°-156° C.

1. additionwas added
2. dissolutiondissolve
3. distillationThe solvent was distilled off
4. customthe residue was crystallized from acetone-ether
5. filtrationThe resulting crystals were collected by filtration
6. washwashed with ether