4-(9-Xanthenylidene)piperidine → 4-[4-(9-Xanthenylidene)piperidino]-2-butanone

Participants

Reaction Steps

One drop of tribenzylmethyl ammonium hydroxide is added to a solution of 7 g of 4-(9-xanthenylidene)-piperidine in 70 cc of ethanol, 4.38 cc of methylvinylketone are then added dropwise, and stirring is effected at 50° for 4 hours. The reaction mixture is then concentrated by evaporation in a vacuum, the residue is dissolved in chloroform, extraction is effected with water, and after drying over magnesium sulphate, concentration is effected by evaporation. The partially crystalline residue is triturated with ether/petroleum ether 1:1 and recrystallized from ethanol. M.P. of the title compound 111°-112°.

Provenance & Evidence