Formaldehyde → HCID 86735458, compound

Participants

Reaction Steps

In Scheme B serine is converted to 2-amino-3-hydroxy-2-hydroxymethylpropionic acid by reaction with aqueous sodium carbonate containing an excess of formaldehyde. From that point the synthesis is conducted as set out in Scheme A. However, it is preferable to activate 2-amino-3-hydroxy-2-hydroxymethylpropionic acid with 1-hydroxy benzotriazole to facilitate condensation with p- N,N-bis(2-chloroethyl)!phenylendediamine. The product, 2-amino-N- p-bis(2-chloroethyl)amino!phenyl-3-hydroxy-2-hydroxymethylpropionamide, is isolated as the hydrochloride salt. As in Scheme A, the hydrochloric acid may be replaced with those indicated acids.

Provenance & Evidence