HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl acetoacetate → 6-Octynoic acid, 3-oxo-, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-Bromo-2-butyne | HCID 2756862 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | 6-Octynoic acid, 3-oxo-, methyl ester | HCID 11469295 | — |
Reaction Steps
In accordance with the process of Reference 1, sodium hydride (550 mg; 23 m mol), methyl acetoacetate; (2.56 g; 22 m mol), n-butyl lithium (23 m mol) and 4-bromo-2-butyne were used to obtain 2.53 g of 3-oxo-6-octynoic acid methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04073799 |
| Source dataset | uspto-grants-1978_02 |
| ORD ID | ord-ca0c92fc0af64ec7b210e2e8c8eab5f8 |
| Source note | uspto-grants-1978_02 |