Hydrogen chloride-ethyl acetate → HCID 178449159, compound

HRID 616334Notes

Reaction equation

HRID 616334 reaction equation
[N:1]#[N:2].C([O:7][C:8](=[O:36])[CH2:9][N:10]([C:15](=[O:35])[C@H:16]([CH2:28][CH2:29][CH2:30][NH:31][C:32](=[NH:34])[NH2:33])[NH:17][S:18]([C:21]1[CH:27]=[CH:26][C:24]([CH3:25])=[CH:23][CH:22]=1)(=[O:20])=[O:19])[CH2:11][CH2:12][CH2:13][CH3:14])(C)(C)C.[ClH:37].C(OCC)(=O)C>C(Cl)(Cl)Cl>[N:1]#[N:2].[ClH:37].[S:18]([NH:17][C@H:16]([C:15]([N:10]([CH2:11][CH2:12][CH2:13][CH3:14])[CH2:9][C:8]([OH:36])=[O:7])=[O:35])[CH2:28][CH2:29][CH2:30][NH:31][C:32](=[NH:33])[NH2:34])([C:21]1[CH:27]=[CH:26][C:24]([CH3:25])=[CH:23][CH:22]=1)(=[O:19])=[O:20]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178449152HCID 178449152, compound

Product 1

HCID 178449159HCID 178449159, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 2.0 g of N2 -tosyl-L-arginyl-N-butylglycine tert-butyl ester in 20 ml of chloroform was added 50 ml of 15% HCl-ethyl acetate. The reaction mixture was stirred for 5 hours at room temperature. At the end of this period, the reaction mixture was evaporated to dryness. The residue was washed several times with dry ethyl ether to give 1.5 g of N2 -tosyl-L-arginyl-N-butylglycine hydrochloride as an amorphous solid. I.R. (KBr): 3,340, 3,180, 1,640 cm-1

Workup

  1. customAt the end of this period, the reaction mixture was evaporated to dryness
  2. washThe residue was washed several times with dry ethyl ether

Sources & evidence

ORD record
ord-7006725b0c7649ecb44e23aebca37a18
Source dataset
uspto-grants-1978_02
Patent number
US04073891

Reaction notes

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