Diethyl Ether → Hydrogen maleate

Participants

Reaction Steps

1 g of 1-(3-isopropyl-2-phenyl-5-oxazolidinylmethoxy)-7-methoxy-isoquinoline is heated to 80° in 10 cc of 1 N hydrochloric acid for 10 minutes. The reaction mixture is extracted with ether. The ethereal phase is discarded, and the aqueous phase is made alkaline with potash, extracted with ether, the ether phase is dried over magnesium sulphate and concentrated, whereby a crystalline product is obtained which is treated in methanol with maleic acid. Ether is added, whereby 1-(2-hydroxy-3-isopropylaminopropoxy)-7-methoxyisoquinoline is obtained as hydrogen maleate. M.P. 144°-146°.

Provenance & Evidence