HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium → 1-(3-Isopropyl-2-phenyl-5-oxazolidinylmethoxy)-7-methoxyisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium | HCID 5462222 | — |
| Reactant | 2-Phenyl-3-isopropyl-5-hydroxymethyloxazolidine | HCID 12566198 | — |
| Reactant | 1-Chloro-7-methoxyisoquinoline | HCID 22250181 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | 1-(3-Isopropyl-2-phenyl-5-oxazolidinylmethoxy)-7-methoxyisoquinoline | HCID 20369801 | — |
Reaction Steps
0.3 g of potassium are dissolved in 15 cc of absolute tert.butanol, and 1.5 g of 1-chloro-7-methoxyisoquinoline and 1.7 g of 5-hydroxymethyl-3-isopropyl-2-phenyl-oxazolidine are added. The solution is heated to 50° for 1 hour, whereupon it is evaporated to dryness. The product is digested with water, extracted with ether, the ether phase is dried and the ether is distilled off. 1-(3-isopropyl-2-phenyl-5-oxazolidinylmethoxy)-7-methoxyisoquinoline is obtained as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04073909 |
| Source dataset | uspto-grants-1978_02 |
| ORD ID | ord-d9cd9279a49b469c95c1d0b594710e72 |
| Source note | uspto-grants-1978_02 |