Ethyl bromoacetate → 66935-31-7

Participants

Reaction Steps

To a stirred solution of 165.2 g of 2-methoxyethylamine and 202.4 g of triethylamine in 1 l of benzene was added dropwise to a solution of 334.0 g of ethyl bromoacetate in 200 ml of benzene in 1 hour at room temperature. At the end of this period, the mixture was heated at reflux for 2 hours to complete the reaction. Upon chilling, the triethylamine hydrochloride was removed by filtration and washed with benzene. After removal of the solvent, the product was distilled in vacuo to yield 242.8 g (75.3 percent) of N-(2-methoxyethyl)glycine ethyl ester, B. P. 73°-5° C/4 mmHg.

Provenance & Evidence