Methanol → HCID 20388954, compound

Participants

Reaction Steps

A mixture of 31.7 g of 2-methyl-5-thiazole-propanoic acid, 3.2 ml of concentrated sulfuric acid and 300 ml of methanol was refluxed for 16 hours and was concentrated under reduced pressure. The mixture was added to 100 ml of water and concentrated ammonium hydroxide was added to obtain a pH of 12-13. The mixture was extracted with methylene chloride and the organic extracts were dried over magnesium sulfate and concentrated to dryness under reduced pressure to obtain 35 g of raw methyl 2-methyl-5-thiazole-propanoate. The hydrochloride thereof melted at 115° C.

Provenance & Evidence