Diethyl Ether → HCID 178422819, compound

HRID 616382Notes

Reaction equation

HRID 616382 reaction equation
[N:1]#[N:2].[CH3:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][C:10]([S:14]([NH:17][C@H:18]([C:26]([OH:28])=O)[CH2:19][CH2:20][CH2:21][NH:22][C:23](=[NH:25])[NH2:24])(=[O:16])=[O:15])=[CH:11]2)=[CH:6][CH:5]=1.C(OCC)C.S(Cl)([Cl:36])=O>>[N:1]#[N:2].[ClH:36].[CH3:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][C:10]([S:14]([NH:17][C@H:18]([C:26]([Cl:36])=[O:28])[CH2:19][CH2:20][CH2:21][NH:22][C:23](=[NH:25])[NH2:24])(=[O:16])=[O:15])=[CH:11]2)=[CH:6][CH:5]=1

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 24386Thionyl ChlorideHCID 178422820HCID 178422820, compound

Product 1

HCID 178422819HCID 178422819, compound

Procedure

A suspension of 2.5 g of N2 -(7-methyl-2-naphthalenesulfonyl)-L-arginine in 20 ml of thionyl chloride was stirred for 2 hours at room temperature. Addition of cold dry diethyl ether resulted in a precipitate which was collected by filtration and washed several times with dry diethyl ether to give N2 -(7-methyl-2-naphthalenesulfonyl)-L-arginyl chloride hydrochloride.

Workup

  1. customresulted in a precipitate which
  2. filtrationwas collected by filtration
  3. washwashed several times with dry diethyl ether

Sources & evidence

ORD record
ord-3b83aa6837894e1b82095cbcb59675de
Source dataset
uspto-grants-1978_02
Patent number
US04073916

Reaction notes

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