HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → HCID 20369935, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | HCID 23458801 | HCID 23458801 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Product | HCID 20369935 | HCID 20369935 | — |
Reaction Steps
Methyl 2-acetamido-2-methyl-3-(3-nitro-4-acetamidophenyl)propionate is treated with hydrogen, formaldehyde, sodium acetate and Raney nickel following the procedure of part B of Example 4 to produce 2-acetamido-2-methyl-3(3-methylamino-4-aminophenyl)propionic acid. This product is hydrolyzed with 10% HCl and cyclized with phosgene by the procedure of part B of Example 4 to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04073929 |
| Source dataset | uspto-grants-1978_02 |
| ORD ID | ord-ab9f003e46f3424c992ab3143e31896e |
| Source note | uspto-grants-1978_02 |