反应详情

Formaldehyde solution (150 ml of 40% solution) was added with stirring to a solution of dimethylamine (218g of 26% solution) and malonic acid (104g) in water (250 ml). The reaction temperature was kept at 20° C during the addition and for a further 2 hours. The solution was then heated on a steam bath for 2 hours and the water was removed under reduced pressure to give a pale yellow syrup which was dried further by azeotropic distillation with benzene.

1. additionThe reaction temperature was kept at 20° C during the addition and for a further 2 hours
2. temperatureThe solution was then heated on a steam bath for 2 hours
3. customthe water was removed under reduced pressure
4. customto give a pale yellow syrup which
5. dry with materialwas dried further by azeotropic distillation with benzene