Amantadine → HCID 70622003, compound

Participants

Reaction Steps

A mixture of 15 g. of 2-(3-bromopropylthio)-5-chlorobiphenyl and an excess of 1-aminoadamantane was heated in an oil bath at about 120° C. for about 4 hours. The reaction mixture was worked up and the product was isolated as the hydrochloride acid addition salt in the manner described in previous examples. The product had a melting point of about 304°-305° C., and was identified as N-adamantyl-3-(5-chloro-2-biphenylylthio)propylamine hydrochloride.

Provenance & Evidence