Methyl Isocyanate → HCID 20367573, compound

Participants

Reaction Steps

A mixture of 9.8 g of 5-amino-4-cyano-3-(diethylamino)isothiazole, 20 drops of dibutyltin diacetate, and about 15 ml of methyl isocyanate in 50 ml of dry tetrahydrofuran was heated under reflux for 21 hours, at which time thin-layer chromatographic analysis indicated reaction to be complete. The solution was concentrated under reduced pressure and the residue was recrystallized from ethanol to give 11.7 g of white 1-methyl-3-(4-cyano-3-(diethylamino)-5-isothiazolyl)urea, m.p. 182°-183°. The nmr spectrum was consistent with the assigned structure.

Provenance & Evidence