反应详情

温度

60 °C

To an ice-cooled mixture of 39.2 g of 2,4,6-triethyl-2,6-dimethyl-1,2,5,6-tetrahydropyrimidine and 18.0 g of methyl ethyl ketone were added 14.7 g of powdered calcium chloride dihydrate, followed by 3 ml of water. The resulting mixture was heated at 60° C, with stirring, for 15 hours, made alkaline by the addition of a 35% aqueous solution of sodium hydroxide and extracted with diethyl ether. The etheral solution was then dried over potassium carbonate and the diethyl ether was evaporated off. The residue was distilled under reduced pressure, giving 32.4 g of the title compound. Boiling point 91° - 93° C/2.0 mmHg.

1. extractionextracted with diethyl ether
2. dry with materialThe etheral solution was then dried over potassium carbonate
3. customthe diethyl ether was evaporated off
4. distillationThe residue was distilled under reduced pressure