反应详情

11.1 g of the 2,4-diethyl-4-methyl-1,5-diazaspiro[5.5]-undec-1-ene thus obtained and 2.5 g of ammonium bromide were dissolved in 70 ml of methanol. 45 ml of water were added to the solution, with stirring. The mixture was then stirred at room temperature for 8 hours. Methanol was removed by evaporation under reduced pressure and the residue was then distilled under reduced pressure, giving 7.4 g of the title product, bp 119° - 122° C/1.5 mmHg.

1. stirringThe mixture was then stirred at room temperature for 8 hours
2. customMethanol was removed by evaporation under reduced pressure
3. distillationthe residue was then distilled under reduced pressure