Ethyl orthoformate → HCID 20368032, compound

HRID 616557Notes

Reaction equation

HRID 616557 reaction equation
[CH:1](OCC)(OCC)OCC.[NH2:11][C:12]1[C:17]([SH:18])=[N:16][C:15]([Cl:19])=[C:14]([Cl:20])[N:13]=1>>[Cl:20][C:14]1[N:13]=[C:12]2[N:11]=[CH:1][S:18][C:17]2=[N:16][C:15]=1[Cl:19]

Participants

3

Reactant 2

HCID 31214Ethyl orthoformateHCID 178508439HCID 178508439, compound

Product 1

HCID 20368032HCID 20368032, compoundYield 75%

Procedure

To 100 ml. of triethyl orthoformate was added 9.8 g (0.05 mole) of 2-amino-5,6-dichloro-3-mercaptopyrazine. The whole was heated to boiling under reflux for 20 hours, cooled to room temperature and filtered, washed with petroleum-ether and dried to give 7.7 g. (75% yield) of the desired product, m.p. 124°-5° C.

Workup

  1. temperatureThe whole was heated
  2. temperatureunder reflux for 20 hours
  3. filtrationfiltered
  4. washwashed with petroleum-ether
  5. customdried
  6. customto give 7.7 g

Sources & evidence

ORD record
ord-712ff09d310846b795774c17a0ecfd33
Source dataset
uspto-grants-1978_02
Patent number
US04075207

Reaction notes

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