Ethyl orthoformate → HCID 20368034, compound

HRID 616558Notes

Reaction equation

HRID 616558 reaction equation
[CH2:1](OC(OCC)OCC)C.[NH2:11][C:12]1[C:13]([SH:20])=[N:14][C:15]([Br:19])=[C:16]([Br:18])[N:17]=1>>[Br:18][C:16]1[N:17]=[C:12]2[N:11]=[CH:1][S:20][C:13]2=[N:14][C:15]=1[Br:19]

Participants

3

Reactant 2

HCID 31214Ethyl orthoformateHCID 178508266HCID 178508266, compound

Product 1

HCID 20368034HCID 20368034, compoundYield 73%

Procedure

Fifty ml. of triethylorthoformate and 8.6 g. of 3-amino-5,6-dibromopyrazinethiol were mixed and heated to boiling under reflux for 22 hours. The reaction mixture was then concentrated under reduced pressure and diluted with petroleum-ether. The resulting precipitate of yellowish brown crystalline material weighed 6.7 g. (73% yield), m.p. 142°-4° C.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 22 hours
  3. concentrationThe reaction mixture was then concentrated under reduced pressure
  4. additiondiluted with petroleum-ether

Sources & evidence

ORD record
ord-73b36702586f404c99e24df98f54a767
Source dataset
uspto-grants-1978_02
Patent number
US04075207

Reaction notes

Loading…