HCID 178422346, compound → HCID 178422347, compound

Participants

Reaction Steps

23.5 g. of 6-chloro-2-methylpyrazolo[1,5-a]pyrido[4,3-d]pyrimidin-9(4H)-one of Example 3 are hydrogenated at 80° in 200 ml. of dimethylformamide in the presence of 15 g. of triethylamine and 10% palladium on charcoal as catalyst. When the theoretical amount of hydrogen has been absorbed, the reaction mixture is filtered hot and the mother liquor evaporated in vacuo to dryness. The remaining 2-methylpyrazolo[1,5-a]pyrido[4,3-d]pyrimidin-9(4H)-one is recrystallized from dimethylformamide, yield: 18.5 g. (92%); m.p. >300°.

Provenance & Evidence