Sodium methanethiolate → HCID 20368069, compound

Participants

Reaction Steps

0.1 mole of 6-chloro-2,4-dimethylpyrazolo[1,5-a]pyrido[4,3-d]pyrimidin-9(4H)-one of Example 5 is suspended in 100 ml. of dimethylformamide. 0.15 mole of sodium methyl mercaptide is added and the mixture is heated at reflux temperature with stirring for 10 hours. After this time, the precipitated sodium chloride is filtered off and 100 ml. of water are added. 2,4-dimethyl-6-(methylthio)pyrazolo[1,5-a]pyrido[4,3-d]pyrimidin-9(4H)-one crystallizes and is filtered off, yield: 73%; m.p. >300° (butyl alcohol).

Provenance & Evidence