Sulfuric Acid → HCID 14953204, compound

HRID 616591Notes

Reaction equation

HRID 616591 reaction equation
[NH:1]([C:3]1[CH2:4][C:5](=[O:21])[N:6]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:7]2[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:8]=2[N:9]=1)[NH2:2].[CH:22](OCC)(OCC)OCC.S(=O)(=O)(O)O>>[Cl:14][C:12]1[CH:11]=[CH:10][C:8]2[N:9]3[CH:22]=[N:2][N:1]=[C:3]3[CH2:4][C:5](=[O:21])[N:6]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:7]=2[CH:13]=1

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 31214Ethyl orthoformateHCID 12264322HCID 12264322, compound

Product 1

HCID 14953204HCID 14953204, compound

Procedure

2-Hydrazino-7-chloro-4,5-dihydro-5-phenyl-3H-1,5-benzodiazepin-4-one is heated with triethyl orthoformate and concentrated sulfuric acid. The mixture is stirred for 30 minutes to give 8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,5]benzodiazepine-5(6H)-one.

Sources & evidence

ORD record
ord-d7341adb91614ad5adc822d290a54ffb
Source dataset
uspto-grants-1978_02
Patent number
US04075202

Reaction notes

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