Hydrogen Peroxide → HCID 20310616, compound

Participants

Reaction Steps

A solution of 3 gm. of 9-trifluoromethylthio- 6,11-dihydro-5H-pyrrolo[2,1-b][3]benzazepin-11-one in 25 ml. of acetic acid containing 3 ml. of 50% hydrogen peroxide is stirred at 25° C. for 6 hr. The solvent is evaporated and the residue dissolved in 100 ml. of methylene chloride. The solution is washed with 2 × 25 ml. of 5% Na2CO3 solution, dried and evaporated. Chromatography of the residue on silica gel yields 9-trifluoromethylsulfinyl-6,11- dihydro-5H-pyrrolo [2,1-b][3]benzazepin-11-one.

Provenance & Evidence