反应详情

A mixture of 12.0 g. of the product from Example 1 and 35 g. of pyridine hydrochloride was refluxed for 30 minutes. The hot reaction mixture then was poured over ice, and the mixture was transferred to a blender, homogenized, and the resulting crystals were collected by filtration, washed with water, and dried in vacuo at 80° C. to give 11.0 g. (96 percent) of the title compound, m.p. 204°-205° C.

1. additionA mixture of 12.0 g
2. additionThe hot reaction mixture then was poured over ice
3. filtrationthe resulting crystals were collected by filtration
4. washwashed with water
5. customdried in vacuo at 80° C.
6. customto give 11.0 g